When it comes to disinfecting a mattress after dealing with an illness like COVID-19, it’s important to focus on thorough cleaning and disinfecting measures that are both effective and safe for the mattress material. Start with stripping the bed of all linens and washable items in the hottest water recommended for those fabrics, commonly believed to help kill viruses. For the mattress itself, vacuum it thoroughly, then use a disinfectant spray that’s safe for fabrics, or make a mixture of isopropyl alcohol and water (keeping in mind that 70% solution of isopropyl alcohol is recommended for disinfection). Spray lightly, avoiding saturation, and allow it to air dry completely. Lastly, consider using a mattress protector for easier cleaning in the future.
Cleaning and Disinfecting: A Step-by-Step Guide
Step 1: Strip and Sanitize Bedding
Begin the disinfecting process by removing all bedding, including sheets, mattress covers, and pillowcases. These items should be laundered at the highest temperature recommended on the care labels. Adding a disinfectant to the wash can provide additional reassurance, but remember to use a product appropriate for the fabric type to avoid damage.
Step 2: Vacuum the Mattress Surface
Before applying any liquid solutions, vacuum the mattress with an upholstery attachment. This step removes debris and dust, which can harbor pathogens. Be thorough, and don’t forget to vacuum the sides of the mattress as well.
Step 3: Choosing the Right Disinfectant
Select a disinfectant that’s effective against viruses and safe for fabrics. Many commercial disinfectants can work, or you could opt for a homemade solution of 70% isopropyl alcohol mixed with water. Ensure the disinfectant is EPA-registered, and check if it lists effectiveness against viruses like coronavirus.
Our Top 5 Mattress Picks
Updated September 2026EGOHOME 8-Inch Green Tea Memory Foam Mattress, Full, Medium Firm
Best for most bedrooms. A medium-firm green tea memory foam mattress with a cooling gel layer, delivered rolled in a box.
- Full size, 8 in
- Medium firm
- Cooling green tea gel
- CertiPUR-US, fiberglass free
OhGeni Queen Air Mattress with Built-in Pump, 18-Inch Raised
Best for guests and camping. Inflates in about three minutes with the built-in pump and sits 18 inches off the floor, so it feels like a real bed.
- Queen, 18 in raised
- Built-in pump
- 800 lb capacity
- Waterproof PVC
Novilla 6-Inch Gel Memory Foam Mattress, Twin
Best budget twin. A slim gel memory foam twin that suits kids' rooms, bunk beds and trundles where a thick mattress won't fit.
- Twin, 6 in
- Gel memory foam
- Cooling
- CertiPUR-US
Zinus 8-Inch Green Tea Memory Foam Mattress, Twin
Best-known brand. Zinus's long-running green tea foam design in twin size, with both CertiPUR-US and OEKO-TEX certified materials.
- Twin, 8 in
- Green tea memory foam
- CertiPUR-US & OEKO-TEX
GAESTE 8-Inch Cooling Gel Memory Foam Mattress, Full, Medium Feel
Best for hot sleepers. Cooling gel memory foam with a medium feel, plus a machine-washable, anti-slip cover you can actually clean.
- Full size, 8 in
- Medium feel
- Cooling gel foam
- Washable cover
- Fiberglass free
Step 4: Application of Disinfectant
Lightly spray the disinfectant across the entire surface of the mattress. Do not oversaturate, as this can promote mold and mildew growth within the mattress. Focus on areas that come into direct contact with the person who was sick, and ensure you cover all sides of the mattress.
Step 5: Air Out the Mattress
After applying the disinfectant, let the mattress air out until it’s completely dry. This may take several hours. If possible, increase airflow in the room by opening windows or using fans to speed up the drying process.
Step 6: Additional Disinfection Methods
In addition to disinfectant sprays, consider using a steam cleaner, which can kill pathogens using high heat. Be aware, though, that some mattresses aren’t suitable for this treatment, so check the manufacturer’s recommendations before proceeding.
Step 7: Protective Measures
After disinfecting your mattress, adding a mattress protector can provide a barrier against contaminants. Protectors can be easily removed and machine-washed, simplifying future disinfecting efforts.
Step 8: Maintenance and Prevention
To prevent future contamination, regularly wash bedding, and consider using antimicrobial sheets or protectors. Maintaining a clean bedroom environment can also reduce the likelihood of pathogen buildup on your mattress and other surfaces.
Understanding Disinfectants and Mattress Materials
Not all disinfectants are created equal, nor are all mattresses. It’s important to tailor your approach to the type of mattress you have. Memory foam, innerspring, latex, and hybrid mattresses each react differently to moisture and chemicals.
Memory Foam Mattresses
These are particularly sensitive to moisture, so a light application of disinfectant is crucial. Soaking a memory foam mattress can damage its structure and promote the growth of mold.
Innerspring and Hybrid Mattresses
The coils inside these mattresses can rust if the disinfectant penetrates too deeply. A light misting is preferred, and ensure thorough drying to prevent internal dampness.
Latex Mattresses
Natural latex can be degraded by certain chemicals, so it’s essential to use a gentle disinfectant and avoid products containing harsh solvents or acidic components.
It is also worthwhile investigating whether the disinfectant you plan to use leaves a residue that could attract dirt over time or potentially cause skin irritations. Always follow the manufacturer’s guidelines for both the disinfectant product and your mattress.
Homemade Solutions and Natural Alternatives
For those who prefer a more natural approach, certain homemade solutions can be effective for disinfection without the use of harsh chemicals. While isopropyl alcohol solutions are one option, others include:
Vinegar and Essential Oils
A mixture of white vinegar with a few drops of essential oils like tea tree or lavender can offer mild disinfecting properties and a more pleasant scent. However, the efficacy of vinegar as a disinfectant against viruses like COVID-19 is not as well-established as commercial disinfectants or alcohol solutions.
Baking Soda
While not a disinfectant, baking soda can help deodorize the mattress after illness. Sprinkle a thin layer on the mattress, let it sit for several hours, and vacuum it thoroughly.
Remember, these natural alternatives may not be as effective at killing pathogens as EPA-registered disinfectants or alcohol-based solutions. If in doubt, especially after illness, the priority should be to use a product known to be effective against viruses.
Finishing Thoughts
Disinfecting your mattress after an illness like COVID-19 is an essential step in ensuring a clean and safe recovery environment. While it takes a bit of effort, the steps are simple: strip the bed, wash all fabrics at a high temperature, choose the right disinfectant, apply it properly, ensure thorough drying, and consider the ongoing protection of your mattress. Remember that each mattress is different, and what works for one may not be suitable for another. Safety and prevention are key – by maintaining a clean bedroom and using protective barriers like mattress protectors, you can help keep your sleeping space sanitary and supportive of good health.
